TTIP is being negotiated by EU Trade Commissioner Cecilia Malmström and by the United States Trade Representative Michael Froman. The European Commission coordinates its negotiating position closely with the member states.

On the European side, the negotiations are being headed by the European Commission, and within that body the Directorate-General for Trade. EU Commissioner for Trade Cecilia Malmström is the commissioner who is politically responsible for the TTIP negotiations. Ignacio Garcia Bercero from the Directorate-General for Trade is the main negotiator for the European Commission.

The member states of the EU issued a mandate to the European Commission to conduct negotiations with the U.S. on 14 June 2013.

The EU has designated heads of negotiation for the more than 20 working groups; their names can be found on the Commission's website. The EU's leading negotiators are supported by experts from the various Directorates-General of the European Commission and the various regulatory authorities. Furthermore, the European Commission appointed a 14-person advisory board at the end of January 2014; it consists of experts from different sectors of the economy, as well as consumer protection experts and trade union representatives.

On the U.S. side, the U.S. Trade Representative Michael Froman (Office of the United States Trade Representative - USTR) bears political responsibility. The chief negotiator on the U.S. side is Dan Mullaney. For additional information about the U.S. negotiators, please consult the website of the USTR at www.ustr.gov/ttip.